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Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior

Year: 2006
Type: article
Abstract: Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines in the CA1 hippocampal pyramidal cells. Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior.
DOI: 10.1093/hmg/ddl402
Authors: Ichiko Nishijima, Takanori Yamagata, Corinne M. Spencer, Edwin J. Weeber, Olga Alekseyenko, J. David Sweatt, Mariko Y. Momoi, Masayuki Ito, Dawna L. Armstrong, David L. Nelson, Richard Paylor, Allan Bradley
Institutions: Abigail Wexner Research Institute, The Ohio State University, Jichi Medical University, Vanderbilt University, National Center of Neurology and Psychiatry, Baylor College of Medicine, Wellcome Sanger Institute
Language: English
Field: Psychology
Open Access status: hybrid
Estimated APC paid: $4,390
OpenAlex ID: W2168354739
FWCI: 3.784
Cites: 65
Cited by: 58
Related to: 10