Work

Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus

Year: 2013

Type: article

Abstract: New neurons, which have been implicated in pattern separation, are continually generated in the dentate gyrus in the adult hippocampus. Using a genetically modified rabies virus, we demonstrated that molecular layer perforant pathway (MOPP) cells innervated newborn granule neurons in adult mouse brain. Stimulating the perforant pathway resulted in the activation of MOPP cells before the activation of dentate granule neurons. Moreover, activation of MOPP cells by focal uncaging of glutamate induced strong inhibition of granule cells. Together, these results indicate that MOPP cells located in the molecular layer of the dentate gyrus contribute to feed-forward inhibition of granule cells via perforant pathway activation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1306912110

Authors: Yan Li, Floor J. Stam, James B. Aimone, Martyn Goulding, Edward M. Callaway, Fred H. Gage

Institution: Salk Institute for Biological Studies

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze