Barleria Montana Wight and Nees–a Promising Natural Anti-inflammatory Agent Against Formalin Induced Inflammation
Year: 2015
Type: article
Abstract: Objective: To evaluate the anti-inflammatory activity of the ethanolic leaf extract of Barleria montana ( B. montana ) against formalin induced inflammation. Methods: Male albino wistar rats were pretreated with oral doses of 100 mg, 200 mg and 300 mg of the extract for 30 days and the animals received a single dose of sub plantar injection of formalin (0.1 ml/kg body weight (bw.)) Indomethacin (25 mg/kg bw.) was used as the standard drug. The effect of the extract on paw thickness, biochemical and hematological parameters was investigated along with histopathological studies. Results: The results revealed that the extract exhibited an effective dose dependent activity against formalin induced inflammation with a maximum activity at a dosage of 300 mg/kg bw. which was comparable with the standard drug. Conclusion: The results signify promising activity of ethanolic leaf extract of B. montana against formalin induced inflammation in albino rats. The extract was also found to exhibit appreciable antioxidant activity.
Authors: Sriram Sridharan, M. Venkatramani, Kavitha Janakiraman, Brindha Pemiah, Sasikumar Chinnagounder
Institution: SASTRA University
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2168514020