Year: 2014
Type: letter
Abstract: patients for whom the benefit of prolonged maintenance TMZ is unclear.Nonetheless, the use of 12 cycles of post-RT TMZ in patients with newly diagnosed GBM is a common practice, notwithstanding the lack of evidence to support prolonged maintenance TMZ.These comments are not meant to diminish the significant efforts by the RTOG study group but rather to ask whether this study is practice changing?No, although we should acknowledge the substudy of net clinical benefit contained within RTOG 0525 that highlights a hitherto neglected dimension of treatment effect and that will likely become a new standard assessment instrument in randomized trials of gliomas. 7Are the results sufficiently different than currently used therapies?No, RT plus TMZ remains the standard of care for protocol eligible young patients with newly diagnosed GBM.Might there be an opportunity to further refine the approach to GBM? Absolutely, but the challenge has been how and with what novel therapy.
Source: Journal of Clinical Oncology
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2168541013