Work

Splicing of Rhesus Rhadinovirus R15 and ORF74 Bicistronic Transcripts during Lytic Infection and Analysis of Effects on Production of vCD200 and vGPCR

Year: 2005

Type: article

Abstract: Rhesus macaque rhadinovirus (RRV) is the rhesus macaque homologue of human herpesvirus 8 (HHV-8). Here we examine expression of RRV R15 and ORF74, homologues of K14 and ORF74 of HHV-8, respectively. As in HHV-8, transcripts encoding RRV R15 and ORF74 are bicistronic. However, unlike what has been suggested for HHV-8, RRV R15- and ORF74-encoding transcripts are expressed late during lytic infection and undergo unique splicing events that result in the production of transcripts capable of encoding vGPCR, as well as membrane-associated and secreted forms of vCD200. The alternative splicing for vCD200 has implications for viral pathogenesis.

Source: Journal of Virology

DOI: 10.1128/jvi.79.6.3878-3882.2005

Authors: Carly L. Pratt, Ryan D. Estep, Scott W. Wong

Institutions: Oregon Health & Science University, Vaccine and Gene Therapy Institute, Oregon National Primate Research Center

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Center for Research Resources