Genome-wide Association Scan for Childhood Caries Implicates Novel Genes
Year: 2011
Type: article
Study design: Observational Study
Abstract: Dental caries is the most common chronic disease in children and a major public health concern due to its increasing incidence, serious health and social co-morbidities, and socio-demographic disparities in disease burden. We performed the first genome-wide association scan for dental caries to identify associated genetic loci and nominate candidate genes affecting tooth decay in 1305 US children ages 3-12 yrs. Affection status was defined as 1 or more primary teeth with evidence of decay based on intra-oral examination. No associations met strict criteria for genome-wide significance (p < 10E-7); however, several loci (ACTN2, MTR, and EDARADD, MPPED2, and LPO) with plausible biological roles in dental caries exhibited suggestive evidence for association. Analyses stratified by home fluoride level yielded additional suggestive loci, including TFIP11 in the low-fluoride group, and EPHA7 and ZMPSTE24 in the sufficient-fluoride group. Suggestive loci were tested but not significantly replicated in an independent sample (N = 1695, ages 2-7 yrs) after adjustment for multiple comparisons. This study reinforces the complexity of dental caries, suggesting that numerous loci, mostly having small effects, are involved in cariogenesis. Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries.
Source: Journal of Dental Research
Authors: J.R. Shaffer, X. Wang, E. Feingold, M. Lee, F. Begum, D.E. Weeks, K.T. Cuenco, M.M. Barmada, S.K. Wendell, D.R. Crosslin, C.C. Laurie, K.F. Doheny, E.W. Pugh, Q. Zhang, B. Feenstra, F. Geller, H.A. Boyd, H. Zhang, M. Melbye, J.C. Murray, R.J. Weyant, R. Crout, D.W. McNeil, S.M. Levy, R.L. Slayton, M.C. Willing, B. Broffitt, A.R. Vieira, M.L. Marazita
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
Awards: G1338396984, Longitudinal Study of Fluoride, Diet, Caries & Fluorosis, Fluoride & Other Factors in Childhood and Adolescent Bone Development, Genome-wide association studies of prematurity and its complications, Dental Caries: Whole Genome Association and Gene x Environment Studies, Factors Contributing to Oral Health Disparities in Appalachia, Genome Wide Association Coordinating Center, University of Pittsburgh Clinical and Translational Science Institute, JH/CIDR Genotyping for Genome-Wide Association Studies, Statistical Modeling and Genetic Epidemiology of Dental Caries in GWAS Analysis, G8267674335, COMPREHENSIVE PROGRAM FOR CRANIOFACIAL &DENTAL ANOMALIE
OpenAlex ID: W2168552231