Work

Behavioral outcome measures used for human neural stem cell transplantation in rat stroke models

Year: 2011

Type: article

Abstract: Stroke is a leading cause of death and disability, leading to the development of various stroke models to test new treatments, most commonly in the rat. Human stroke trials focus on disability, related primarily to neurological deficits. To better model the clinical application of these treatments, many behavioral tests have been developed using the rat stroke model. We performed a systematic review of all the behavioral outcome measures used in published studies of human neural stem cell transplantation in rat stroke models. The reviewed tests include motor, sensory, cognitive, activity, and combination tests. For each test, we give a brief description, trace the origin of the test, and discuss test performance in the reviewed studies. We conclude that while many behavioral tests are available for this purpose, there does not appear to be consensus on an optimal testing strategy.

Source: Neurology International

DOI: 10.4081/ni.2011.e10

Authors: Matthew B. Jensen, Dong Y. Han, Abdullah Al Sawaf, Rajeev Krishnaney-Davison

Institution: University of Wisconsin–Madison

Language: English

Topic: Stroke Rehabilitation and Recovery

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,930