Work

PEG-Polypeptide Dual Brush Block Copolymers: Synthesis and Application in Nanoparticle Surface PEGylation

Year: 2013

Type: article

Abstract: Amphiphilic polypeptide-containing hybrid dual brush block copolymers with controlled molecular weights and narrow molecular weight distributions were synthesized in one pot via ring-opening metathesis polymerization of sequentially added norbornyl-PEG and N -(2-((trimethylsilyl)amino)ethyl)-5-norbornene-endo-2,3-dicarboximide (M1), followed by ring-opening polymerization of amino acid N -carboxyanhydrides. Polylactide nanoparticles coated with these amphiphilic dual brush block copolymers showed significantly improved stability in PBS solution compared to those coated with amphiphilic linear block copolymers such as PEG-polylactide and PEG-polypeptides.

Source: ACS Macro Letters

DOI: 10.1021/mz4003672

Authors: Yanfeng Zhang, Qian Yin, Hua Lu, Hongwei Xia, Yao Lin, Jianjun Cheng

Institutions: University of Illinois Urbana-Champaign, University of Connecticut

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health

Award: Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates