Age and cystatin C in healthy adults: a collaborative study
Year: 2009
Type: article
Abstract: BACKGROUND: Kidney function declines with age, but a substantial portion of this decline has been attributed to the higher prevalence of risk factors for kidney disease at older ages. The effect of age on kidney function has not been well described in a healthy population across a wide age spectrum. METHODS: The authors pooled individual-level cross-sectional data from 18 253 persons aged 28-100 years in four studies: the Cardiovascular Health Study; the Health, Aging and Body Composition Study; the Multi-Ethnic Study of Atherosclerosis and the Prevention of Renal and Vascular End-Stage Disease cohort. Kidney function was measured by cystatin C. Clinical risk factors for kidney disease included diabetes, hypertension, obesity, smoking, coronary heart disease, cerebrovascular disease, peripheral arterial disease and heart failure. RESULTS: Across the age range, there was a strong, non-linear association of age with cystatin C concentration. This association was substantial, even among participants free of clinical risk factors for kidney disease; mean cystatin C levels were 46% higher in participants 80 and older compared with those <40 years (1.06 versus 0.72 mg/L, P < 0.001). Participants with one or more risk factors had higher cystatin C concentrations for a given age, and the age association was slightly stronger (P < 0.001 for age and risk factor interaction). CONCLUSIONS: There is a strong, non-linear association of age with kidney function, even in healthy individuals. An important area for research will be to investigate the mechanisms that lead to deterioration of kidney function in apparently healthy persons.
DOI: 10.1093/ndt/gfp474
Institutions: University of California, San Francisco, University of California, Berkeley, University Medical Center Groningen, University of Groningen, University of Washington, VA Pittsburgh Healthcare System, University of Pittsburgh, University of Tennessee Health Science Center, National Institutes of Health, National Institute on Aging, Tufts Medical Center, San Francisco VA Medical Center
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Robert Wood Johnson Foundation, American Federation for Aging Research, American Heart Association, Nierstichting, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke
Awards: G100949702, G1083180012, G1200636938, G1220223050, G1261793039, G1401438683, G1409423729, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1686417863, G1778933655, G1837979145, G1890355377, G1916108176, G1951774866, G1982334678, SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER, G2194386449, ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE, G2585438117, G277826483, G2800149121, G2815873878, G290884426, G3137375862, G3145043064, G328935669, G3370719899, G3639969904, G3647016462, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4012114008, G4048755144, G423252844, Long Term Effects of Subclinical CAD on Cardiac Function, G4653673457, G4660668308, G5167412771, G5234713383, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTER, G5654179670, G5755700318, G581554933, CHS Events Follow-up Study, G6217957645, G6226795708, Training In Clinical Investigation in Kidney and Urology, G670738241, G6832344490, G687544517, G693548699, G7201305826, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, G766843672, G7706274302, G7781883235, G783845518, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G7999488110, G806768229, G8593276544, G859984287, G861947890, CHS-Transition Phase -268055222, G8821123181, G9000006353, G9000027259, G9000065698, G9000069887, G9000105012, G9000145448, G9000155493, G9000159977, G9000239991, G9000294005, G9000318776, G905887895, G991334795
OpenAlex ID: W2168676452