Work

Structure and distribution of pentapeptide repeats in bacteria

Year: 1998

Type: article

Abstract: We report the discovery of a novel family of proteins, each member contains tandem pentapeptide (five residue) repeats, described by the motif A(D/N)LXX. Members of this family are both membrane bound and cytoplasmic. The function of these repeats is uncertain, but they may have a targeting or structural function rather than enzymatic activity. This family is most common in cyanobacteria, suggesting a function related to cyanobacterial-specific metabolism. Although no experimental information is available for the structure of this family, it is predicted that the tandem pentapeptide repeats will form a right-handed beta-helical structure. A structural model of the pentapeptide repeats is presented.

Source: Protein Science

DOI: 10.1002/pro.5560070625

Authors: Alex Bateman, Alexey G. Murzin, Sarah A. Teichmann

Institutions: MRC Laboratory of Molecular Biology, Wellcome Sanger Institute, Wellcome Trust, Medical Research Council

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Wellcome Trust, Boehringer Ingelheim Fonds, Medical Research Council

OpenAlex ID: W2168757976

FWCI: 0.568

Cites: 24

Cited by: 99

Related to: 10