Work

The MGH Miniature Swine as a Large Animal Model of HCT and Graft Versus Host Disease

Year: 2013

Type: article

Abstract: Graft-versus-host disease (GVHD) remains a frequent complication of hematopoietic cell transplantation (HCT) with skin being a principal target organ. Murine models have provided some insight into the mechanisms of this complex disease process. However, mouse skin differs from human skin, and results of studies in rodents may not translate well to the clinic. The pig is a well-recognized animal model for preclinical studies of skin including dermal toxicology, transdermal drug delivery and wound healing.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.411

Authors: Raimon Duran-Struuck, George F. Murphy, Roderick T. Bronson, David H. Sachs, Christene A. Huang, Thomas R. Spitzer

Institutions: Harvard University, Massachusetts General Hospital, Brigham and Women's Hospital

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650