Work

Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier

Year: 2002

Type: article

Abstract: We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.46.8.2633-2635.2002

Authors: William A. Banks, Michael L. Niehoff, Robert L. Brown, Zhi-Yuan Chen, Thomas E. Cleveland

Institutions: Veterans Health Administration, Saint Louis University, Agricultural Research Service, Louisiana State University

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke