Work

Modulation of J774.1 Macrophage l- Arginine Metabolism by Intracellular Mycobacterium bovis BCG

Year: 2003

Type: article

Abstract: Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more (3)H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of (3)H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.

Source: Infection and Immunity

DOI: 10.1128/iai.71.2.1011-1015.2003

Authors: Marcy A. Peteroy-Kelly, Vishwanath Venketaraman, Meliza Talaue, Anjali Seth, Nancy D. Connell

Institutions: International Center for Public Health, Rutgers New Jersey Medical School

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases

Award: NUTRIENT TRANSPORT MECHANISMS IN MYCOBACTERIA