Year: 2007
Type: article
Abstract: UNLABELLED: Small-animal imaging systems are often characterized using phantoms, which may not predict performance in clinical applications. An implantable synthetic SPECT lesion would facilitate characterization of lesion detectability in a living animal. METHODS: Anion-exchange columns with bed volumes of 100-300 nL were constructed from medical-grade polyvinyl chloride tubing and resin. The columns were tested in an excised mouse femur and implanted in the femur of a living mouse. Imaging was performed using a prototype dual-modality SPECT/CT system. RESULTS: Activity of 7.4-22.2 MBq (0.2-0.6 mCi) localized within the synthetic lesion. The synthetic lesions were reused multiple times. Mice tolerated the implanted columns without complications for up to 8 wk. CONCLUSION: A reusable, synthetic SPECT lesion was constructed and implanted in the femur of a living mouse. The synthetic lesion is useful for the development of imaging schemes and for more realistically evaluating imaging-system performance in the context of a living animal.
Source: Journal of Nuclear Medicine
Authors: M. B. Abbott, L. R. Furenlid, D. W. Wilson, G. D. Stevenson, J. M. Woolfenden, H. H. Barrett
Institution: University of Arizona
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: Center for Gamma-Ray Imaging
OpenAlex ID: W2168904263