Response to Comment on: Keenan et al. (2010) Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study. Diabetes 2010;59:2846–2853
Year: 2010
Type: article
Abstract: e appreciate the response by Rother and Harlan (1) to our article (2).However, it is difficult to understand what the confirmatory aspects of the Medalist Study data are with respect to the studies of Liu et al. (3) and Rother et al. ( 4), which documented minimal levels of C-peptide production in individuals with a diabetes duration of 19.2 Ϯ 11.8 years and 21.3 Ϯ 10.7 years, respectively.Clearly, this duration is significantly lower than the Medalists' mean duration of 56.2 Ϯ 5.8 years.Another difference is the relationship of disease duration and residual C-peptide production, which was not significant in the Medalist Study but was reported to be significant in the article by Liu et al., with a statistically higher mean duration (P ϭ 0.0045) in those patients without (26.2Ϯ 13.1 years) than those patients with residual C-peptide production (19.2 Ϯ 11.8 years) (3).One of the most important components of our study is the pre-and post mortem data on nine Medalists.Ours is the first study to show a correlation between random C-peptide, physiological response to stimulation, and insulin positive -cell mass in any human population of type 1 diabetic patients and, extraordinarily, in individuals with
Source: Diabetes
DOI: 10.2337/db10-1277
Institutions: Joslin Diabetes Center, Harvard University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2169197950