Impact of Long-Term Cryopreservation on Single Umbilical Cord Blood Transplantation Outcomes
Year: 2014
Type: article
Study design: Observational Study
Abstract: Umbilical cord blood (UCB) may be collected and cryopreserved for years before use. In vitro and murine models suggest that the duration of storage does not affect UCB progenitor cell performance; however, the impact of UCB age on clinical outcomes has not been definitely defined. This study sought to determine the effect of UCB unit cryopreservation time on hematopoietic potency. We analyzed 288 single UCB units used for transplantation from 1992 to 2013, with unit cryopreservation time ranging from .08 to 11.07 years. UCB unit post-thaw characteristics were examined, including percent recovery of total nucleated cells (TNC). The number of years the UCB unit spent in cryopreservation had no impact on TNC recovery nor UCB unit post-thaw viability. Duration of cryopreservation also had no impact on neutrophil or platelet engraftment in single UCB transplantations. These results show that UCB units can undergo cryopreservation for at least 10 years with no impact on clinical outcomes.
Institution: University of Minnesota
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
Awards: University of Minnesota Clinical and TranslationalmScience Institute (UMN CTSI), Lymphoid Tissue Inducer/NK22 Cells and Post-transplant Immune Recovery, Perivascular Cell Characterization and Contribution to the Hematopoietic Niche, Cancer Center Support Grant, Off-the-Shelf Immune Effector Cells for Hematological Malignancies
OpenAlex ID: W2169218639