Delivery of host cell-directed therapeutics for intracellular pathogen clearance
Year: 2013
Type: article
Abstract: Intracellular pathogens present a major health risk because of their innate ability to evade clearance. Their location within host cells and ability to react to the host environment by mutation or transcriptional changes often enables survival mechanisms to resist standard therapies. Host-directed drugs do not target the pathogen, minimizing the potential development of drug resistance; however, they can be difficult to deliver efficiently to intracellular sites. Vehicle delivery of host-mediated response drugs not only improves drug distribution and toxicity profiles, but can reduce the total amount of drug necessary to clear infection. In this article, we will review some host-directed drugs and current drug delivery techniques that can be used to efficiently clear intracellular infections.
Authors: Michael A Collier, Matthew D Gallovic, Kevin J Peine, Anthony D Duong, Eric M Bachelder, John S Gunn, Larry S Schlesinger, Kristy M Ainslie
Institution: The Ohio State University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2169314128