Work

Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON-TB Gold Assay Results

Year: 2009

Type: article

Abstract: To evaluate the utility of the QuantiFERON-TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON-TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON-TB Gold assay to monitor therapy.

Source: Infection Control and Hospital Epidemiology

DOI: 10.1086/596606

Authors: Nira R. Pollock, Suely S. Kashino, Danielle R. Napolitano, Alex Sloutsky, Swati Joshi, Jasmine Guillet, Michael Wong, Edward Nardell, Antonio Campos-Neto

Institutions: Beth Israel Deaconess Medical Center, The Forsyth Institute, Brigham and Women's Hospital, University of Massachusetts Chan Medical School

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Pfizer, Massachusetts Institute of Technology, National Institute of Allergy and Infectious Diseases

Awards: TB Vaccine Candidates Found in Patients' Bodily Fluids and Murine MHC-1 Molecule, Development and Evaluation of a Novel Diagnostic Test for Active Tuberculosis

OpenAlex ID: W2169606758

FWCI: 1.833

Cites: 10

Cited by: 32

Related to: 10