Work

A Porphyrin Increases Survival Time of Mice after Intracerebral Prion Infection

Year: 2006

Type: article

Abstract: Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.50.2.759-761.2006

Authors: David A. Kocisko, Winslow S. Caughey, Richard E. Race, Grant Roper, Byron Caughey, John D. Morrey

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Utah State University

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases