Effect of Pioglitazone on Body Fat and Intramuscular Fat Accumulation in Otsuka Long- Evans Tokushima Fatty Rats : Its Relation to the Expression of Tumor Necrosis Factor-alpha mRNA (Original)
Year: 2003
Type: article
Abstract: The effects of pioglitazone on body fat and intramuscular fat accumulation and its relation to the expression of tumor necrosis factor (TNF)-α mRNA were examined in Otsuka Long-Evans Tokushima Fatty rats.Eight-week-old rats were divided into pioglitazone,glibenclamide,gliben-clamide＋pioglitazone, and control groups and monitored for 12 weeks.Body weight, adipose tissue weight, and triglyceride content in skeletal muscle were significantly higher in the pioglitazone group than in the control group and in the glibenclamide＋pioglitazone group than in the glibenclamide group.Plasma levels of insulin,free fatty acids,triglycerides,and total cholesterol, TNF-α expression in adipose tissue,and triglyceride content in liver were significantly lower and in adipose tissue numbers of large adipocytes were lower and numbers of small adipocytes were greater in the pioglitazone group than in the control group and in the glibenclamide＋pioglitazone group than in the glibenclamide group.These results suggest that pioglitazone decreases TNF-α expression in adipose tissue and decreases insulin resistance by reducing the size of adipocytes.In addition, pioglitazone might also affect adipocytes in skeletal muscle the same way as those in adipose tissue.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W611607540