Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age
Year: 2009
Type: article
Abstract: Life span can be extended in rodents by restricting food availability (caloric restriction [CR]) or by providing food low in methionine (Meth-R). Here, we show that a period of food restriction limited to the first 20 days of life, via a 50% enlargement of litter size, shows extended median and maximal life span relative to mice from normal sized litters and that a Meth-R diet initiated at 12 months of age also significantly increases longevity. Furthermore, mice exposed to a CR diet show changes in liver messenger RNA patterns, in phosphorylation of Erk, Jnk2, and p38 kinases, and in phosphorylation of mammalian target of rapamycin and its substrate 4EBP1, HE-binding protein 1 that are not observed in liver from age-matched Meth-R mice. These results introduce new protocols that can increase maximal life span and suggest that the spectrum of metabolic changes induced by low-calorie and low-methionine diets may differ in instructive ways.
Authors: L. Sun, A. A. Sadighi Akha, R. A. Miller, J. M. Harper
Institutions: University of Michigan, Ann Arbor VA Medical Center
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: bronze
Awards: CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTER, G1233934336, G2967753411, G3031150197, Longevity genes and calorie restriction: early post-natal effects, G4498387036, Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center), Longevity Consortium
OpenAlex ID: W2169829560