Work

Myeloid-derived suppressor cells and the efficacy of CD8+T-cell immunotherapy

Year: 2013

Type: article

Abstract: Myeloid-derived suppressor cells (MDSCs) promote immune evasion, a key feature of oncogenesis. The restoration of immunosurveillance by immunomodulatory antibodies improves the survival of a subset of cancer patients. Preclinical studies suggest that the ablation of monocytic MDSCs may be a useful adjunct to available immunotherapeutic strategies against cancer.

Source: OncoImmunology

DOI: 10.4161/onci.22764

Authors: Alexander M. Lesokhin, Taha Merghoub, Jedd D. Wolchok

Institution: Memorial Sloan Kettering Cancer Center

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913