Inflammatory Plasma Markers and Pancreatic Cancer Risk: A Prospective Study of Five U.S. Cohorts
Year: 2013
Type: article
Study design: Observational Study
Abstract: Chronic inflammation may play a role in the development of pancreatic cancer. However, few prospective studies have examined the association between plasma inflammatory markers and pancreatic cancer risk. Therefore, we investigated the association of prediagnostic circulating C-reactive protein (CRP), interleukin-6 (IL-6), and TNF-α receptor II (TNF-αR2) with subsequent pancreatic cancer risk in a prospective, nested case-control study of 470 cases and 1,094 controls from Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, Women's Health Initiative, and Women's Health Study. The median follow-up time of cases was 7.2 years (range 1-26 years). No association was observed between plasma CRP, IL-6, and TNF-αR2 and the risk of pancreatic cancer. Comparing extreme quintiles, the multivariate ORs were 1.10 [95% confidence interval (CI), 0.74-1.63; Ptrend = 0.81] for CRP, 1.19 (95% CI, 0.81-1.76; Ptrend = 0.08) for IL-6, and 0.88 (95% CI, 0.58-1.33; Ptrend = 0.57) for TNF-αR2. In conclusion, prediagnostic levels of circulating CRP, IL-6, and TNF-αR2 were not associated with the risk of pancreatic cancer, suggesting that systemic inflammation as measured by circulating inflammatory factors is unlikely to play a major role in the development of pancreatic cancer.
Authors: Ying Bao, Edward L. Giovannucci, Peter Kraft, Zhi Rong Qian, Chen Wu, Shuji Ogino, J. Michael Gaziano, Meir J. Stampfer, Jing Ma, Julie E. Buring, Howard D. Sesso, I-Min Lee, Nader Rifai, Michael N. Pollak, Li Jiao, Lawrence Lessin, Barbara B. Cochrane, JoAnn E. Manson, Charles S. Fuchs, Brian M. Wolpin
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1011819373, CLIN CTR FOR THE CLIN TRIAL & OBSERVATIONAL STUDY OF WHI, G1053650685, Women's Health Initiative, Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, Women's Health Initiative, Women's Health Initiative, G1168185457, Women's Health Initiative, G1327305488, Women's Health Initiative, G1423636853, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, Prospective Cohort Collaborative in Pancreatic Cancer Epidemiology & Pathogenesis, Women's Health Initiative, G1828895303, Cohort Study of Biochemical and Genetic Risk Factors for Pancreatic Cancer, G1938127574, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G2145550945, G229684361, G2449723990, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, Women's Health Initiative, G3064351193, Women's Health Initiative, Women's Health Initiative Memory Study (WHIMS), G3370718536, G3426488059, Women's Health Initiative, Women's Health Initiative, Dietary and Hormonal Determinants of Cancer in Women, Women's Health Initiative, Women's Health Initiative, G425643165, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, Women's Health Initiative, G4522543292, Women's Health Initiative, G4582778782, Women's Health Initiative, Women's Health Initiative, G5143030701, FOR ALL FIELD CENTER FOR WHI EXTENSION, Women's Health Initiative, Physicians' Health Study II: Prevention Trial of Vitamins, G5448612825, Women's Health Initiative, G558986044, G5684079324, Women's Health Initiative, G5953211031, G6008908520, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G6577455577, Women's Health Initiative, Women's Health Initiative, Women's Health Initiative, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, Women's Health Initiative, G7001937487, G7030479240, Prospective Studies of Diet and Cancer in Men and Women, Women's Health Initiative, Women's Health Initiative, CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHI, G7554740352, Women's Health Initiative, CLINICAL CENTER FOR THE CLINICAL TRIAL & OBSERVATIONAL STUDY OF WHI, Women's Health Study: Continued Follow-up, G8174553142, G8554986239, G885693336, G9000002220, G9000007102, G9000009796, G9000015938, G9000016408, G9000029166, G9000032408, G9000044693, G9000056195, G9000070405, G9000072420, G9000083979, G9000085703, G9000087561, G9000099044, G9000099165, G9000118125, G9000128615, G9000138615, G9000149325, G9000151586, G9000173839, G9000203926, G9000217803, G9000230008, G9000232007, G9000236644, G9000237972, G9000240728, G9000282402, G9000284018, G9000284434, G9000285876, G9000305396, G9000309661, G9000321316, G9000334721, G9000342364, G9000343153, G9000346400, G9000351987, G9000355101, Women's Health Initiative
OpenAlex ID: W2170188548