Year: 2014
Type: preprint
Abstract: Regeneration of injured adult skeletal muscle involves fusion of activated satellite cells to form new myofibers. Myomaker is a muscle-specific membrane protein required for fusion of embryonic myoblasts, but its potential involvement in adult muscle regeneration has not been explored. We show that myogenic basic helix-loop-helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration. Moreover, genetic deletion of myomaker in adult satellite cells completely abolishes muscle regeneration, resulting in severe muscle destruction after injury. Myomaker is the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult myoblasts.
Source: Genes & Development
Institution: The University of Texas Southwestern Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: Deciphering a Regulatory Circuit for Myocardial Metabolism and Energy Homeostasis, Heart Repair through Reprogramming of Cardiac Cell Fate, MicroRNA Control of Cardiac Gene Expression, Function and Disease, G6054505128, Microenvironmental control of progenitors in organ dysfunction and repair, G662211534, Metabolic Control by Myogenic MicroRNAs, Mediator and Myokines
OpenAlex ID: W2170191823