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The Integrated Web Portal for Escalation with Overdose Control (EWOC)

Year: 2013
Type: article
Abstract: In this paper, we present the design and implementation of a novel web portal for the cancer phase I clinical trial design method Escalation with Overdose Control (EWOC). The web portal has two major components: a web-based dose finding calculator; and a standalone and downloadable dose finding software which can be installed on Windows operating systems. The web-based dose finding calculator uses industry standards and is a database-driven and distributed computing platform for designing and conducting dose finding in cancer phase I clinical trials utilizing EWOC methodology. The web portal is developed using open source software: PHP, JQuery, R and OpenBUGS. It supports any standard browsers with internet connection. The web portal can be accessed at: http://biostatistics.csmc.edu.
DOI: 10.2174/1874-431120130427001
Authors: Haibin Wang, Mourad Tighiouart, Shao-Chi Huang, Dror Berel, Galen Cook-Wiens, Catherine Bresee, Quanlin Li, André Rogatko
Language: English
Open Access status: hybrid
Awards: G1120375403, UCLA Clinical and Translational Science Institute, IBD: Role of Genetic and Immunopathologic Mechanisms, G2417647834, G2663518188, Prostate Cancer Bone Metastasis Biology and Targeting, G2989067737, UCLA Clinical and Translational Science Institute, G9000267277
OpenAlex ID: W2170321327
FWCI: 0.293
Cites: 10
Cited by: 2
Related to: 10