Work

Controlled Release of Proteins to Tissue Transplants for the Treatment of Neurodegenerative Disorders

Year: 1996

Type: review

Abstract: Alzheimer's disease involves substantial cholinergic cell deficits; other neurodegenerative diseases involve similar losses of certain cell populations. Optimal therapies may involve tissue replacement coupled with the controlled delivery of appropriate growth factors, such as nerve growth factor, to the graft site. In this review article we describe the kinetics of protein release from three modes of controlled protein delivery to transplants: delivery from a polymer matrix, delivery form polymeric microspheres, and delivery from genetically engineered cells. The efficacy and feasibility of each of these delivery strategies for potential treatment of patients diagnosed with neurodegenerative disorders is discussed.

Source: Journal of Pharmaceutical Sciences

DOI: 10.1021/js9601602

Authors: Melissa J. Mahoney, W. Mark Saltzman

Institutions: Johns Hopkins University, Cornell University

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Aeronautics and Space Administration