Work

Embryonic Heart Progenitors and Cardiogenesis

Year: 2013

Type: preprint

Abstract: The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). This review will focus on molecular cues necessary for proper induction, expansion, and lineage-specific differentiation of these progenitor populations during cardiac development in vivo. Moreover, we will briefly discuss how the knowledge gained on embryonic heart progenitor biology can be used to develop novel therapeutic strategies for the management of congenital heart disease as well as for improvement of cardiac function in ischemic heart disease.

Source: Cold Spring Harbor Perspectives in Medicine

DOI: 10.1101/cshperspect.a013847

Authors: T. Brade, L. S. Pane, A. Moretti, K. R. Chien, K.-L. Laugwitz

Institutions: TUM Klinikum, Technical University of Munich, German Centre for Cardiovascular Research, Harvard University, Karolinska Institutet

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsches Zentrum für Herz-Kreislaufforschung, Deutsche Forschungsgemeinschaft