KIR-HLA Genotypes Have No Identifiable Role in Unit Predominance Following Double Unit Cord Blood Transplantation
Year: 2011
Type: article
Abstract: Double unit cord blood transplantation (DCBT) is a frequent strategy to augment graft cell dose. However, in the majority of patients, donor hematopoiesis is accounted for by one unit, although the mechanisms of unit dominance are not established. Cord blood NK cells are predominantly of a mature phenotype, with cytotoxic activity following IL-2 stimulation comparable to peripheral blood NK cells, but with higher proliferation capacity. We, therefore, hypothesized that NK cells may determine unit dominance following DCBT.
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2170493717