Multicenter Study of Isavuconazole MIC Distributions and Epidemiological Cutoff Values for the Cryptococcus neoformans-Cryptococcus gattii Species Complex Using the CLSI M27-A3 Broth Microdilution Method
Year: 2014
Type: article
Abstract: Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.
DOI: 10.1128/aac.04055-14
Institutions: Virginia Commonwealth University Medical Center, University of Delhi, Universidad Autónoma de Nuevo León, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Canisius-Wilhelmina Ziekenhuis, Radboud University Medical Center, University of California Davis Medical Center, The University of Adelaide
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2170609888