Work

Coding potential of laboratory and clinical strains of human cytomegalovirus

Year: 2003

Type: article

Abstract: Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have been passaged to a limited extent in the laboratory (Toledo, FIX, PH, and TR). All of the sequenced viral genomes have been cloned as infectious bacterial artificial chromosomes. A total of 252 ORFs with the potential to encode proteins have been identified that are conserved in all four clinical isolates of the virus. Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2136652100

Authors: Eain Murphy, Dong Yu, Jane Grimwood, Jeremy Schmutz, Mark Dickson, Michael A. Jarvis, Gabriele Hahn, Jay A. Nelson, Richard M. Myers, Thomas E. Shenk

Institutions: Oregon Health & Science University, Princeton University, Stanford Medicine, Vaccine and Gene Therapy Institute, Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität München, Stanford University

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Energy, Wilhelm Sander-Stiftung, National Institutes of Health, Office of Science, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Biological and Environmental Research

Awards: G3964159556, Human Cytomegalovirus Tegument Proteins, HERPESVIRUS PERSISTENCE AND ONCOGENICITY, Molecular Aspects of Cytomegalovirus Latency, G9000097804, Molecular Aspects of Cytomegalovirus Latency

OpenAlex ID: W2170651190

FWCI: 10.46

Cites: 49

Cited by: 509

Related to: 10