Work

Mechanisms of Tubulointerstitial Fibrosis

Year: 2010

Type: review

Abstract: The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis. Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in recent decades, effective human treatment to directly halt or even reverse fibrosis remains elusive. Here, we examine key features mediating the molecular and cellular basis of tubulointerstitial fibrosis and highlight new insights that may lead to novel therapies. How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding.

Source: Journal of the American Society of Nephrology

DOI: 10.1681/asn.2010080793

Authors: Michael Zeisberg, Eric G. Neilson

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Vanderbilt University

Language: English

Topic: Chronic Kidney Disease and Diabetes

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Scheme for Promotion of Academic and Research Collaboration, National Institute of Diabetes and Digestive and Kidney Diseases