Uncovering Drug-Responsive Regulatory Elements
Year: 2015
Type: review
Abstract: Nucleotide changes in gene regulatory elements can have a major effect on interindividual differences in drug response. For example, by reviewing all published pharmacogenomic genome-wide association studies, we show here that 96.4% of the associated single nucleotide polymorphisms reside in noncoding regions. We discuss how sequencing technologies are improving our ability to identify drug response-associated regulatory elements genome-wide and to annotate nucleotide variants within them. We highlight specific examples of how nucleotide changes in these elements can affect drug response and illustrate the techniques used to find them and functionally characterize them. Finally, we also discuss challenges in the field of drug-responsive regulatory elements that need to be considered in order to translate these findings into the clinic.
Source: Pharmacogenomics
DOI: 10.2217/pgs.15.121
Authors: Marcelo R Luizon, Nadav Ahituv
Institution: University of California, San Francisco
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G187421119, Characterization of neuronal gene regulatory elements associated with epilepsy, Pharmacogenomics of Membrane Transporters, Identification & functional characterization of SIM1 obesity-associated variants, Integrative interpretation of the organismal consequences of non-coding variation, Pharmacogenetics of Membrane Transporters
OpenAlex ID: W2170791339