Work

Impulsive and Compulsive Behaviors in Parkinson's Disease

Year: 2013

Type: review

Abstract: Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.

Source: Annual Review of Clinical Psychology

DOI: 10.1146/annurev-clinpsy-032813-153705

Authors: B.B. Averbeck, S.S. O'Sullivan, A. Djamshidian

Institutions: National Institutes of Health, National Institute of Mental Health, University College Cork, Cork University Hospital, University of London

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institutes of Health