Work

Loss of PKCλ/ι impairs Th2 establishment and allergic airway inflammation in vivo

Year: 2009

Type: article

Abstract: The differentiation of T cells along different lineages is central to the control of immunity. Here we have used a conditional gene knockout system to delete PKC lambda/iota selectively in activated T cells. With this system we have demonstrated that PKC lambda/iota is necessary for T-helper cell (Th2) cytokine production and optimal T-cell proliferation and allergic airway inflammation in vivo. Our data demonstrate that the activation of the transcription factors nuclear factor of activated T cells and NF-kappaB is impaired in PKC lambda/iota-deficient activated T cells. In addition, we present genetic knockout evidence in ex vivo experiments with primary T cells that PKC lambda/iota is critical for the control of cell polarity during T-cell activation. Therefore PKC lambda/iota emerges as a critical regulator of Th 2 activation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0805907106

Authors: Jun-Qi Yang, Michael Leitges, Angeles Duran, Maria T. Diaz-Meco, Jorge Moscat

Institutions: University of Cincinnati, University of Oslo

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Cincinnati, National Institutes of Health, University of California, San Francisco, National Institute of Allergy and Infectious Diseases