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Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism

Year: 2015
Type: article
Abstract: While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts in nonhuman primates and patients, this approach has not been successful for more immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol resulting in three out of four monkeys achieving long-term lung allograft survival without ongoing immunosuppression. Two of the tolerant monkeys displayed stable mixed lymphoid chimerism, and the other showed transient chimerism. Serial biopsies and post-mortem specimens from the tolerant monkeys revealed no signs of chronic rejection. The tolerant recipients also exhibited T cell unresponsiveness and a lack of alloantibody. This is the first report of durable mixed chimerism and successful tolerance induction of MHC-mismatched lungs in primates.
DOI: 10.1111/ajt.13274
Authors: M. Tonsho, S. Lee, A. Aoyama, S. Boskovic, O. Nadazdin, K. Capetta, R.N. Smith, R.B. Colvin, D.H. Sachs, A.B. Cosimi, T. Kawai, J.C. Madsen, G. Benichou, J.S. Allan
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,300
Funders: Massachusetts General Hospital, American Society of Transplant Surgeons, Yoshida Scholarship Foundation, National Institutes of Health, Chugai Pharmaceutical, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases
Awards: G1917254468, New Approaches to Cardiothoracic Tolerance Induction, THORACIC ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATES, Approaches to Tolerance of Allogeneic Kidney and Islet Transplants, Tolerance Strategies in Non-Human Primate Cardiac Allograft Recipients, Chronic Lung Allograft Rejection in MHC-Defined Swine
OpenAlex ID: W2170975682
FWCI: 8.39
Cites: 30
Cited by: 46
Related to: 10