Work

Studying complex biological systems using multifactorial perturbation

Year: 2003
Type: review
Abstract: High-throughput genomics, transcriptomics, proteomics and metabolomics have the potential to identify the functional consequences of induced and natural genetic variation. Surprisingly, the experiments of most genomics researchers still mainly involve perturbing a biological system of interest by modifying either one factor or one gene at a time. By contrast, this article argues that multifactorial experimentation would allow the study of many more biologically relevant questions in parallel at the same or lower cost.
Language: English
Open Access status: hybrid
OpenAlex ID: W2171151258
FWCI: 1.653
Cites: 47
Cited by: 188
Related to: 10