Recent Advances in Host Defense Mechanisms/ Therapies against Oral Infectious Diseases and Consequences for Systemic Disease
Year: 2014
Type: review
Abstract: The innate and adaptive immune systems are both crucial to oral disease mechanisms and their impact on systemic health status. Greater understanding of these interrelationships will yield opportunities to identify new therapeutic targets to modulate disease processes and/or increase host resistance to infectious or inflammatory insult. The topics addressed reflect the latest advances in our knowledge of the role of innate and adaptive immune systems and inflammatory mechanisms in infectious diseases affecting the oral cavity, including periodontitis and candidiasis. In addition, several potential links with systemic inflammatory conditions, such as cardiovascular disease, are explored. The findings elucidate some of the defense mechanisms utilized by host tissues, including the role of IL-17 in providing immunity to oral candidiasis, the antimicrobial defense of mucosal epithelial cells, and the pro-resolution effects of the natural inflammatory regulators, proresolvins and lipoxins. They also describe the role of immune cells in mediating pathologic bone resorption in periodontal disease. These insights highlight the potential for therapeutic benefit of immunomodulatory interventions that bolster or modulate host defense mechanisms in both oral and systemic disease. Among the promising new therapeutic approaches discussed here are epithelial cell gene therapy, passive immunization against immune cell targets, and the use of proresolvin agents.
Source: Advances in Dental Research
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
Awards: G125298670, G1327225063, Novel Mechanisms in Resolution to Harness Inflammation for Reconstruction, G2519903361, Amelioration of Immune Cell-Mediated Periodontal Disease, G3644596471, IL-17 Receptor Signaling in the Oral Mucosa, Negative Control of IL-17R Signaling: Implications for Fungal Immunity, T-Regulatory Cells in Periodontitis, IL-23/STAT3-Driven Oral Immune Responses to Candida albicans, Neutrophils and Periodontitis in Diabetes, Augmenting Innate Immunity to Protect the Oral Mucosa, REGULATORY CELLS IN EXPERIMENTAL PERIODONTAL DISEASE, G9000014023
OpenAlex ID: W2171215089