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Ion-Channel Gating in Transmembrane Receptor Proteins: Functional Activity in Tethered Lipid Membranes

Year: 1999

Type: article

Abstract: Through thiolipids a planar lipid bilayer (1) was immobilized on a gold support (2) for use as an electrode. This allows the detection of the ligand-gating function of the natural transmembrane channel protein OmpF (3) reconstituted in the artificial membrane: the binding of a domain (4) of the toxin colicin N, observed by surface plasmon resonance, induces the blocking of the OmpF channel protein, as shown by impedance spectroscopy.

Source: Angewandte Chemie International Edition

DOI: 10.1002/(sici)1521-3773(19990201)38:3<389::aid-anie389>3.0.co;2-u

Authors: Thierry Stora, Jeremy H. Lakey, Horst Vogel

Institutions: École Polytechnique Fédérale de Lausanne, Newcastle University

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2171243379

FWCI: 2.49

Cites: 1

Cited by: 123

Related to: 9