Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide
Year: 1999
Type: article
Abstract: Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram-positive and gram-negative bacteria but also broadened the antimicrobial spectrum.
Authors: Manhong Wu, Robert E. W. Hancock
Institution: University of British Columbia
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2171350307