Work

The Dawning of a New Era in the Molecular Biology of the Muscular Dystrophies

Year: 1996

Type: article

Abstract: The Dawning of a New Era in the Molecular Biology of the Muscular DystrophiesDespite decades of intensive research, prior to 1986 the muscular dystrophies could only be characterized according to their clinical and myopathological phenotypes and their modes of inheritance.In the last decade, the discovery of the dystrophin gene (4) and its protein product (3) led to an extensive reclassification of inherited muscle diseases and recognition of a major category of dystrophinopathies and related disorders.This discovery was an important milestone for several reasons.It was the first demonstration of the feasibility of the so-called reverse genetic approach for the identification of a defective gene in a genetic disease.The

Source: Brain Pathology

DOI: 10.1111/j.1750-3639.1996.tb00778.x

Authors: George Karpati, Robert H. Brown

Institutions: Montreal Neurological Institute and Hospital, Massachusetts General Hospital

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2171415201

FWCI: 0.119

Cites: 8

Cited by: 3

Related to: 10