Work

Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo.

Year: 1984

Type: article

Abstract: The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2-restricted, and dose-dependent fashion.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.159.1.234

Authors: J D Tyler, S J Galli, M E Snider, A M Dvorak, D Steinmuller

Institutions: Beth Israel Deaconess Medical Center, Mayo Clinic, Washington University in St. Louis, United States Public Health Service, Harvard University

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Mayo Foundation for Medical Education and Research