Wnt/β-catenin Signaling in Oral Tissue Development and Disease
Year: 2010
Type: review
Abstract: The Wnt/beta-catenin signaling pathway is one of several key conserved intercellular signaling pathways in animals, and plays fundamental roles in the proliferation, regeneration, differentiation, and function of many cell and tissue types. This pathway is activated in a dynamic manner during the morphogenesis of oral organs, including teeth, taste papillae, and taste buds, and is essential for these processes to occur normally. Conversely, forced activation of Wnt/beta-catenin signaling promotes the formation of ectopic teeth and taste papillae. In this review, we discuss our current understanding of the roles of Wnt/beta-catenin signaling in oral tissue development and in related human diseases, and the potential of manipulating this pathway for therapeutic purposes.
Source: Journal of Dental Research
Authors: F. Liu, S.E. Millar
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Functions of Dicer, Drosha and miRNAs in the skin, Modulating Wnt and Hedgehog Pathways for Functional Restoration of Salivary Gland, Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration, WNT signals in developing and postnatal teeth, Intercellular signaling in embryonic and postnatal mammary gland development, WNT signals in skin and hair development and hair growth, Penn Dermatology Research Training Program
OpenAlex ID: W2171636247