Work

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

Year: 2006

Type: preprint

Abstract: We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family. We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Overexpression of SIRT7 increases Pol I-mediated transcription, whereas knockdown of SIRT7 or inhibition of the catalytic activity results in decreased association of Pol I with rDNA and a reduction of Pol I transcription. Depletion of SIRT7 stops cell proliferation and triggers apoptosis. Our findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals.

Source: Genes & Development

DOI: 10.1101/gad.1399706

Authors: Ethan Ford, Renate Voit, Gregory Liszt, Cornelia Magin, Ingrid Grummt, Leonard Guarente

Institutions: Massachusetts Institute of Technology, German Cancer Research Center

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health