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In Vivo Imatinib Sensitivity in a Patient With GI Stromal Tumor Bearing a PDGFRA Deletion DIM842-844

Year: 2014

Type: article

Abstract: In Vivo Imatinib Sensitivity in a Patient With GI Stromal Tumor Bearing a PDGFRA Deletion DIM842-844 Case ReportA 76-year-old Asian man presented with symptoms of postprandial epigastric pain and bloating for 3 months.He denied nausea, vomiting, diarrhea, melana, or hematochezia, but complained of chronic constipation.He was previously diagnosed with irritable bowel syndrome for which he was treated with fiber, dicyclomine, and a Chinese herb after a colonoscopy that revealed a tubulovillous adenoma and melanosis coli.Because of progressive upper abdominal discomfort, a computed tomography (CT) scan of his abdomen and pelvis was performed.Imaging revealed a 13.0-cm mass arising from the retrohepatic space and gastrohepatic ligament.The lesion was abutting the porta hepatis, vena cava, liver, duodenum, and right kidney.Metastatic omental involvement was noted.The primary location of the tumor (ie, stomach or duodenum) was indeterminate; however, given the extent of locally advanced and metastatic disease, the tumor was deemed unresectable.Before referral, percutaneous biopsy of the mass revealed a spindle cell neoplasm that was mostly comprised of epithelioid cells with mildly pleomorphic nuclei on

Source: Journal of Clinical Oncology

DOI: 10.1200/jco.2013.50.0082

Authors: Paul T. Fanta, Jason K. Sicklick, Bryan L. Betz, Michael R. Peterson

Institutions: University of California San Diego, Moores Cancer Center, University of Michigan

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute