Work

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.

Year: 2000

Type: article

Abstract: Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.

Source: Europe PMC (PubMed Central)

Authors: M D Hill, P A Barber, J Takahashi, A M Demchuk, T E Feasby, A M Buchan

Institution: University of Calgary

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2171764120

FWCI: 3.458

Cites: 23

Cited by: 117

Related to: 10