Work

Retinotopic organization of human visual cortex mapped with positron- emission tomography

Year: 1987

Type: article

Abstract: The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated-state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum-detection algorithm to subtraction-format images of the stimulus-induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower-field) caused systematic, highly significant changes in response locale within visual cortex. Discrete extrastriate visual responses were also observed.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.07-03-00913.1987

Authors: PT Fox, FM Miezin, JM Allman, DC Van Essen, ME Raichle

Institutions: California Institute of Technology, Washington University in St. Louis

Language: English

Topic: Visual perception and processing mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke