Work

Physiome‐on‐a‐Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems

Year: 2015

Type: article

Abstract: Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation. This dual approach reduces the need to perfectly rescale and mimic in vivo physiology, an aspiration that is both extremely challenging and not substantively meaningful because of uncertain relevance of any specific physiological condition. Accordingly, this perspective offers a tractable approach for designing interacting MPSs and relating in vitro results to analogous context in vivo.

Source: CPT Pharmacometrics & Systems Pharmacology

DOI: 10.1002/psp4.12042

Authors: CL Stokes, M Cirit, DA Lauffenburger

Institution: Massachusetts Institute of Technology

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $4,140