Does Caloric Restriction Alone Explain the Effects of Roux-en-Y Gastric Bypass on Glucose Metabolism? Not by a Long Limb
Year: 2013
Type: article
Abstract: Among patients with type 2 diabetes, bariatricsurgery has been the subject of considerableinterest because of its favorable effects on glu-cose metabolism. Indeed, various procedures have been associated with high rates of diabetes remission (1), although the outcomes of these studies have been assessed in a heterogeneous manner (2). Despite the fa-vorable results overall, there has been divergence among procedures regarding improvement of diabetes (1). This observation raises the possibility of identifying underlying mechanisms leading to improved glucose metabolism as a means to identify new diabetes treatments. The patho-physiology underlying development of type 2 diabetes in-cludes defects in insulin secretion, disordered postprandial suppression of glucagon secretion, and defects in insulin action and glucose effectiveness (the ability of insulin and glucose to stimulate glucose uptake and suppress glucose release) (3). The heterogeneous effects of various forms of
Source: Diabetes
DOI: 10.2337/db13-0806
Author: Adrian Vella
Institution: Mayo Clinic
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2171811409