Work

Total Synthesis of Sordaricin

Year: 2003

Type: article

Abstract: [structure: see text] The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.

Source: Organic Letters

DOI: 10.1021/ol0342599

Authors: Lewis N. Mander, Regan J. Thomson

Institution: Australian National University

Language: English

Topic: Biological Activity of Diterpenoids and Biflavonoids

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2171830730

FWCI: 0.92

Cites: 13

Cited by: 39

Related to: 10