Work

Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds

Year: 2014

Type: review

Abstract: Heart valve and blood vessel replacement using artificial prostheses is an effective strategy for the treatment of cardiovascular disease at terminal stage. Natural extracellular matrix (ECM)-derived materials (decellularized allogeneic or xenogenic tissues) have received extensive attention as the cardiovascular scaffold. However, the bioprosthetic grafts usually far less durable and undergo calcification and progressive structural deterioration. Glutaraldehyde (GA) is a commonly used crosslinking agent for improving biocompatibility and durability of the natural scaffold materials. However, the nature ECM and GA-crosslinked materials may result in calcification and eventually lead to the transplant failure. Therefore, studies have been conducted to explore new crosslinking agents. In this review, we mainly focused on research progress of ECM-derived cardiovascular scaffolds and their crosslinking strategies.

Source: Regenerative Biomaterials

DOI: 10.1093/rb/rbu009

Authors: B. Ma, X. Wang, C. Wu, J. Chang

Institutions: Chinese Academy of Sciences, Shanghai Institute of Ceramics, State Key Laboratory of High Performance Ceramics and Superfine Microstructure

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820